Perindopril erbumine( —— )

Catalog No. M10292 CAS No. 107133-36-8

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Product Name

Perindopril erbumine
Note

Research use only, not for human use.
Brief Description

PERINDOPRIL ERBUMINE is an angiotensin-converting enzyme inhibitor.
Description

PERINDOPRIL ERBUMINE is an angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.
In Vitro

——
In Vivo

Animal Model:Adenine-induced chronic kidney disease ratsDosage:0.1 mg/kg Administration:Oral gavage (p.o.)Result:Abolished the LPS-induced astroglial and microglial activation.Attenuated LPS-induced TNF-α production.Prevented LPS-induced nuclear translocation of NF-кB.Prevented the AT1R up-regulation and the LPS-induced decrease in the expression of PP2A.Animal Model:Chronic kidney disease rats Dosage:0.42 mg/kg Administration:Oral Result:Obviously reduced serum creatinine (Scr) and blood urea nitrogen (BUN) levels.Displayed a marked reduction of tubulointerstitial fibrosis.Exhibited more inhibitory effect on Col-IV expression and a exceed effect of raising OPA-1 expression.Significantly increased Sirtuin3 expression.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

MRP
Recptor

MRP1| ACE
Research Area

Cardiovascular Disease
Indication

——

CAS Number

107133-36-8
Formula Weight

441.61
Molecular Formula

C23H43N3O5
Purity

>98% (HPLC)
Solubility

Ethanol: 88 mg/mL (199.27 mM); Water: 88 mg/mL (199.27 mM)
SMILES

CCC[C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O.CC(C)(C)N
Chemical Name

——

1.Ceconi C, et al. Eur J Pharmacol, 2007, 577(1-3), 1-6.

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